https://doi.org/10.4081/uij.2017.201

Time of symptom onset and histologic findings in bladder pain syndrome/interstitial cystitis: new findings on useful correlations

Vol. 30 No. 1 (2017)
Submitted: 20 June 2017
Accepted: 2 October 2017
Published: 5 October 2017
Interstitial cystitis, bladder pain syndrome, bladder biopsy, chronic pelvic pain.
Abstract Views: 1037
PDF: 292
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Daniele Porru
danieleporru@tin.it
Department of Urology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Valentina Bobbi
Department of Urology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Carmelo Di Franco
Department of Urology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Alessandra Viglio
Department of Molecular Medicine, Pathology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Mattia Novario
Department of Molecular Medicine, Pathology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Carmine Tinelli
Clinical Epidemiology and Biometric Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Barbara Gardella
Obstetric and Gynecological Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Rossella Nappi
Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, Research Center of Reproductive Medicine, Unit of Gynecological Endocrinology and Menopause, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Arsenio Spinillo
Obstetric and Gynecological Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Marco Paulli
Department of Molecular Medicine, Pathology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Bruno Rovereto
Department of Urology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
The aim was to find out whether a correlation exists between denudation of urothelium and time of symptom onset in patients with bladder pain syndrome/interstitial cystitis (BPS/IC), and to search a correlation between impact of symptoms evaluated with ICSI-ICPI and the presence of comorbid conditions associated with BPS/IC. Ninety-seven consecutive patients underwent cystoscopy under general anesthesia to classify those cases suspected of being affected from BPS/IC. Three cold bladder biopsies were taken including detrusor muscle. Statistical analysis showed significant correlation between IC/BPS duration and the presence of Hunner’s lesions (P<0.023). Hunner’s lesion with cystoscopy and histological evidence of urothelial denudation with bladder biopsy appear to be items related to IC/BPS duration. Thus an early diagnosis allows to start an appropriate therapeutic approach and prevent a more severe evolution of this multifaceted painful syndrome. Our study shows a correlation between time of symptom onset and evidence of urothelial denudation and with detrusor mast cell count in the whole group of patients. IC/BPS duration seem to correlate with the presence of associated diseases.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Daniele Porru, Department of Urology, Fondazione IRCCS Policlinico San Matteo, Pavia

S.C. Urologia

Dirigente medico 1° livello

How to Cite

Porru, D., Bobbi, V., Di Franco, C., Viglio, A., Novario, M., Tinelli, C., Gardella, B., Nappi, R., Spinillo, A., Paulli, M., & Rovereto, B. (2017). Time of symptom onset and histologic findings in bladder pain syndrome/interstitial cystitis: new findings on useful correlations. Urogynaecologia, 30(1). https://doi.org/10.4081/uij.2017.201

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.

An Open Access Publication is one that meets the following two conditions:

  1. the author(s) and copyright holder(s) grant(s) to all users a free, irrevocable, worldwide, perpetual right of access to, and a license to copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship, as well as the right to make small numbers of printed copies for their personal use.
  2. a complete version of the work and all supplemental materials, including a copy of the permission as stated above, in a suitable standard electronic format is deposited immediately upon initial publication in at least one online repository that is supported by an academic institution, scholarly society, government agency, or other well-established organization that seeks to enable open access, unrestricted distribution, interoperability, and long-term archiving.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.