Time of symptom onset and histologic findings in bladder pain syndrome/interstitial cystitis: new findings on useful correlations

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Daniele Porru *
Valentina Bobbi
Carmelo Di Franco
Alessandra Viglio
Mattia Novario
Carmine Tinelli
Barbara Gardella
Rossella Nappi
Arsenio Spinillo
Marco Paulli
Bruno Rovereto
(*) Corresponding Author:
Daniele Porru | danieleporru@tin.it

Abstract

The aim was to find out whether a correlation exists between denudation of urothelium and time of symptom onset in patients with bladder pain syndrome/interstitial cystitis (BPS/IC), and to search a correlation between impact of symptoms evaluated with ICSI-ICPI and the presence of comorbid conditions associated with BPS/IC. Ninety-seven consecutive patients underwent cystoscopy under general anesthesia to classify those cases suspected of being affected from BPS/IC. Three cold bladder biopsies were taken including detrusor muscle. Statistical analysis showed significant correlation between IC/BPS duration and the presence of Hunner’s lesions (P<0.023). Hunner’s lesion with cystoscopy and histological evidence of urothelial denudation with bladder biopsy appear to be items related to IC/BPS duration. Thus an early diagnosis allows to start an appropriate therapeutic approach and prevent a more severe evolution of this multifaceted painful syndrome. Our study shows a correlation between time of symptom onset and evidence of urothelial denudation and with detrusor mast cell count in the whole group of patients. IC/BPS duration seem to correlate with the presence of associated diseases.

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Author Biography

Daniele Porru, Department of Urology, Fondazione IRCCS Policlinico San Matteo, Pavia

S.C. Urologia

Dirigente medico 1° livello