Time of symptom onset and histologic findings in bladder pain syndrome/interstitial cystitis: new findings on useful correlations

Main Article Content

Daniele Porru *
Valentina Bobbi
Carmelo Di Franco
Alessandra Viglio
Mattia Novario
Carmine Tinelli
Barbara Gardella
Rossella Nappi
Arsenio Spinillo
Marco Paulli
Bruno Rovereto
(*) Corresponding Author:
Daniele Porru | danieleporru@tin.it


The aim was to find out whether a correlation exists between denudation of urothelium and time of symptom onset in patients with bladder pain syndrome/interstitial cystitis (BPS/IC), and to search a correlation between impact of symptoms evaluated with ICSI-ICPI and the presence of comorbid conditions associated with BPS/IC. Ninety-seven consecutive patients underwent cystoscopy under general anesthesia to classify those cases suspected of being affected from BPS/IC. Three cold bladder biopsies were taken including detrusor muscle. Statistical analysis showed significant correlation between IC/BPS duration and the presence of Hunner’s lesions (P<0.023). Hunner’s lesion with cystoscopy and histological evidence of urothelial denudation with bladder biopsy appear to be items related to IC/BPS duration. Thus an early diagnosis allows to start an appropriate therapeutic approach and prevent a more severe evolution of this multifaceted painful syndrome. Our study shows a correlation between time of symptom onset and evidence of urothelial denudation and with detrusor mast cell count in the whole group of patients. IC/BPS duration seem to correlate with the presence of associated diseases.

Downloads month by month


Download data is not yet available.

Article Details

Author Biography

Daniele Porru, Department of Urology, Fondazione IRCCS Policlinico San Matteo, Pavia

S.C. Urologia

Dirigente medico 1° livello